Morphine
- Opioid analgesic
- Strong opioid µ receptor agonist
- Activates µ receptors
- ↑ cAMP Opens K & closes Ca channels ↓ release substance P, Inhibits pain @ spinal & supraspinal sites
- Severe pain w/ MI
- Pulmonary edema
- Active metabolite Morphine glucuronate
- Sedation
- Confusion
- Hypotension
- Constipation
- Respiratory depression
- AVOID MAOI w/ 14 d Potentially fatal