Tramadol
- Analgesic
- Dual action
- Activates µ opioid receptors
- Inhibits neuronal reuptake 5-HT & NE
- ↑ inhibition of pain
- Moderate pain
- Chronic pain
- Naloxone reverses some but NOT all Sx
- Dizziness
- HA
- Constipation
- Lowers seizure threshold
- AVOID MAOI
- ↑ risk seizures w/ high doses
- Penicillins
- Phenothiazines