Dihydroergotamine
- Antimigraine
- Ergot alkaloid
- 5-HT 1B/1D receptor agonist Activates 5-HT 1B/1D receptors
- Pial & dural vessel constriction Presynaptic inhibition of trigeminal peptide neurotransmitter release Inhibitions brainstem activation of trigeminal neurons
- Vascular HA Migraine & cluste
- Injection or nasal spray
- N, V
- Stiff neck, shoulder, extremities
- Leg weakness
- Numbness & tingling in fingers & toes